Doing a 1hp quest? Thinking about your go-to items? You might want to think twice. There are a number of items out there that have such bad cards they are "unplayable," but in a 1hp quest they just might fit the bill. Ever equipped Oversize Pick? You're insane! Raging Strike is a brutal card that can absolutely decimate you when it gets drawn, particularly if you have multiples in your deck... unless your whole strategy revolves around never taking damage in the first place! With some rare exceptions where you're using armor to tank your way through a 1hp quest, there's no drawback to cards that increase the damage you take, because if you take any damage you're dead anyway, so the added damage has no effect. These include cards like: Raging Strike Vulnerable Combustible Nightling (against some of the new CM maps) Don't be afraid to give a second look at items that have these cards which you've avoided in normal play. They might just be a piece of the build you've been looking for. Likewise, if you're a fan of: Vengeance Sparkling Cloth Armor Martyr Blessing Think again. These don't give you any bonus unless you actually take damage. Time to shelve those for when you return to normal runs. (Don't confuse this second list with cards that give a bonus when damage is dealt, Mimetic Armor paired with Impenetrable Nimbus actually works really nicely in 1hp quests because it triggers even without damage being taken. Got others to add to either list? I'm sure I've left some off... feel free to share!