That's 48 cards in one hand. There's a 99.9999% chance to block (1 in 1,000,000 chance of block fail) and an average of 13.5 armor. The guillotines don't stand a chance.
You mean NOT excited, right? I don't see this as a good thing, but then again, if you stall for 49 rounds, you should be able to build quite a hand
Simpler is just Punishing Bolt with Spark Generator attached, for a guaranteed hit and an average of 82.5 damage.
The wrong thing to do is a Vampire's Kiss from behind. Or not... With all the Loners, it might be a instant kill too.