Recently, I got to play my brother's account, and the game looks great. I hope I can get into the beta eventually. Anyway, while I was playing I finished a mission and got some cool loot in the treasure chest. The problem is, I clicked the button to continue without looting the chest! So my suggestion is to create a confirmation window that pops up when you click the button to continue without having looted the chest. You could also include the option to turn the confirmation window off, for those who know what they're doing.
Yup, we have threads on that. Gary DOES warn you if you're about to discard high-rarity loot, but otherwise Blue Manchu lets you manipulate all the items one by one and decide what happens. Sometimes you wanna put them in inventory; sometimes you wanna put them on a character. Thus you have the choice. Of course, some people understandably object when you lose precious loot. Others don't like the mechanic at all and want to auto-sell all the "junk" they receive. You can see discussion of this elsewhere.