Hope this is the right place, and I'm not missing something in the rules - Happened several times in the lord stafford mission to various of my characters: Tried to click on a card and it won't allow me to play it.
Any chance you were affected by stuns and such - which makes certain cards unplayable? I can't recall there being any such cards in the adventure however. If it happens again, please read this post and post bugs in the bug subforum.